Journal: Frontiers in Pharmacology
Article Title: Leonurine Improves Age-Dependent Impaired Angiogenesis: Possible Involvement of Mitochondrial Function and HIF-1α Dependent VEGF Activation
doi: 10.3389/fphar.2017.00284
Figure Lengend Snippet: Effects of aging and leonurine on blood flow recuperation. Hindlimb perfusion was measured with TIRI analyzer and expressed by the ischemic/non-ischemic limb temperature ratios. (A) Representative results of TIRI measurements 14 days after hindlimb ischemia operation in different groups of mice. A color scale represents blood flow variations from minimal (dark blue) to maximal (white) values. Arrows indicate ischemic (left) hindlimb. (B) Quantification of Reperfusion values represented by changes in ischemic/non-ischemic limb perfusion. (C) Necrosis scores evaluated on day 14. Values are expressed as mean ± SEM. ∗ p < 0.05 vs. young group; ∗∗ p < 0.01 vs. young group; # p < 0.05 vs. old group; ## p < 0.01 vs. old group. n = 10 for each group.
Article Snippet: All mice skin temperatures of ischemic and non-ischemic hindlimbs were evaluated by the TIRI analyzer (Prism-DS 50137, FLIR Systems), and the color-coded images indirectly denoting changes of blood perfusion.
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